Current methods for hyperpolarized [1-¹³C]pyruvate MRI human studies (2024)

Larson, P. E. Z., Bernard, J. M. L., Bankson, J. A., Bøgh, N., Bok, R. A., Chen, A. P., Cunningham, C. H., Gordon, J. W., Hövener, J. B., Laustsen, C., Mayer, D., McLean, M. A., Schilling, F., Slater, J. B., Vanderheyden, J. L., von Morze, C., Vigneron, D. B., & Xu, D. (Accepted/In press). Current methods for hyperpolarized [1-13C]pyruvate MRI human studies. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.29875

Larson, Peder E.Z. ; Bernard, Jenna M.L. ; Bankson, James A. et al. / Current methods for hyperpolarized [1-13C]pyruvate MRI human studies. In: Magnetic Resonance in Medicine. 2024.

@article{ae4c6978a89548c7a153ead10124e956,

title = "Current methods for hyperpolarized [1-13C]pyruvate MRI human studies",

abstract = "MRI with hyperpolarized (HP) 13C agents, also known as HP 13C MRI, can measure processes such as localized metabolism that is altered in numerous cancers, liver, heart, kidney diseases, and more. It has been translated into human studies during the past 10 years, with recent rapid growth in studies largely based on increasing availability of HP agent preparation methods suitable for use in humans. This paper aims to capture the current successful practices for HP MRI human studies with [1-13C]pyruvate—by far the most commonly used agent, which sits at a key metabolic junction in glycolysis. The paper is divided into four major topic areas: (1) HP 13C-pyruvate preparation; (2) MRI system setup and calibrations; (3) data acquisition and image reconstruction; and (4) data analysis and quantification. In each area, we identified the key components for a successful study, summarized both published studies and current practices, and discuss evidence gaps, strengths, and limitations. This paper is the output of the “HP 13C MRI Consensus Group” as well as the ISMRM Hyperpolarized Media MR and Hyperpolarized Methods and Equipment study groups. It further aims to provide a comprehensive reference for future consensus, building as the field continues to advance human studies with this metabolic imaging modality.",

keywords = "carbon-13, dissolution dynamic nuclear polarization, hyperpolarized MRI, metabolic imaging, pyruvate",

author = "Larson, {Peder E.Z.} and Bernard, {Jenna M.L.} and Bankson, {James A.} and Nikolaj B{\o}gh and Bok, {Robert A.} and Chen, {Albert P.} and Cunningham, {Charles H.} and Gordon, {Jeremy W.} and H{\"o}vener, {Jan Bernd} and Christoffer Laustsen and Dirk Mayer and McLean, {Mary A.} and Franz Schilling and Slater, {James B.} and Vanderheyden, {Jean Luc} and {von Morze}, Cornelius and Vigneron, {Daniel B.} and Duan Xu",

note = "Publisher Copyright: {\textcopyright} 2023 International Society for Magnetic Resonance in Medicine.",

year = "2024",

doi = "10.1002/mrm.29875",

language = "English",

journal = "Magnetic Resonance in Medicine",

issn = "0740-3194",

publisher = "John Wiley & Sons Inc.",

}

Larson, PEZ, Bernard, JML, Bankson, JA, Bøgh, N, Bok, RA, Chen, AP, Cunningham, CH, Gordon, JW, Hövener, JB, Laustsen, C, Mayer, D, McLean, MA, Schilling, F, Slater, JB, Vanderheyden, JL, von Morze, C, Vigneron, DB & Xu, D 2024, 'Current methods for hyperpolarized [1-13C]pyruvate MRI human studies', Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.29875

Current methods for hyperpolarized [1-13C]pyruvate MRI human studies. / Larson, Peder E.Z.; Bernard, Jenna M.L.; Bankson, James A. et al.
In: Magnetic Resonance in Medicine, 2024.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Current methods for hyperpolarized [1-13C]pyruvate MRI human studies

AU - Larson, Peder E.Z.

AU - Bernard, Jenna M.L.

AU - Bankson, James A.

AU - Bøgh, Nikolaj

AU - Bok, Robert A.

AU - Chen, Albert P.

AU - Cunningham, Charles H.

AU - Gordon, Jeremy W.

AU - Hövener, Jan Bernd

AU - Laustsen, Christoffer

AU - Mayer, Dirk

AU - McLean, Mary A.

AU - Schilling, Franz

AU - Slater, James B.

AU - Vanderheyden, Jean Luc

AU - von Morze, Cornelius

AU - Vigneron, Daniel B.

AU - Xu, Duan

N1 - Publisher Copyright:© 2023 International Society for Magnetic Resonance in Medicine.

PY - 2024

Y1 - 2024

N2 - MRI with hyperpolarized (HP) 13C agents, also known as HP 13C MRI, can measure processes such as localized metabolism that is altered in numerous cancers, liver, heart, kidney diseases, and more. It has been translated into human studies during the past 10 years, with recent rapid growth in studies largely based on increasing availability of HP agent preparation methods suitable for use in humans. This paper aims to capture the current successful practices for HP MRI human studies with [1-13C]pyruvate—by far the most commonly used agent, which sits at a key metabolic junction in glycolysis. The paper is divided into four major topic areas: (1) HP 13C-pyruvate preparation; (2) MRI system setup and calibrations; (3) data acquisition and image reconstruction; and (4) data analysis and quantification. In each area, we identified the key components for a successful study, summarized both published studies and current practices, and discuss evidence gaps, strengths, and limitations. This paper is the output of the “HP 13C MRI Consensus Group” as well as the ISMRM Hyperpolarized Media MR and Hyperpolarized Methods and Equipment study groups. It further aims to provide a comprehensive reference for future consensus, building as the field continues to advance human studies with this metabolic imaging modality.

AB - MRI with hyperpolarized (HP) 13C agents, also known as HP 13C MRI, can measure processes such as localized metabolism that is altered in numerous cancers, liver, heart, kidney diseases, and more. It has been translated into human studies during the past 10 years, with recent rapid growth in studies largely based on increasing availability of HP agent preparation methods suitable for use in humans. This paper aims to capture the current successful practices for HP MRI human studies with [1-13C]pyruvate—by far the most commonly used agent, which sits at a key metabolic junction in glycolysis. The paper is divided into four major topic areas: (1) HP 13C-pyruvate preparation; (2) MRI system setup and calibrations; (3) data acquisition and image reconstruction; and (4) data analysis and quantification. In each area, we identified the key components for a successful study, summarized both published studies and current practices, and discuss evidence gaps, strengths, and limitations. This paper is the output of the “HP 13C MRI Consensus Group” as well as the ISMRM Hyperpolarized Media MR and Hyperpolarized Methods and Equipment study groups. It further aims to provide a comprehensive reference for future consensus, building as the field continues to advance human studies with this metabolic imaging modality.

KW - carbon-13

KW - dissolution dynamic nuclear polarization

KW - hyperpolarized MRI

KW - metabolic imaging

KW - pyruvate

UR - http://www.scopus.com/inward/record.url?scp=85186873687&partnerID=8YFLogxK

U2 - 10.1002/mrm.29875

DO - 10.1002/mrm.29875

M3 - Review article

AN - SCOPUS:85186873687

SN - 0740-3194

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

ER -

Larson PEZ, Bernard JML, Bankson JA, Bøgh N, Bok RA, Chen AP et al. Current methods for hyperpolarized [1-13C]pyruvate MRI human studies. Magnetic Resonance in Medicine. 2024. doi: 10.1002/mrm.29875