Perinatal programming of murine immune responses by polyunsaturated fatty acids (2024)

van Vlies, N., Hogenkamp, A., Fear, A. L., van Esch, B. C., Oosting, A., van de Heijning, B., van der Beek, E., Calder, P. C. (2011). Perinatal programming of murine immune responses by polyunsaturated fatty acids. Journal of Developmental Origins of Health and Disease, 2(2), 112-23. https://doi.org/10.1017/S204017441000067X

van Vlies, N ; Hogenkamp, A ; Fear, A L et al. / Perinatal programming of murine immune responses by polyunsaturated fatty acids. In: Journal of Developmental Origins of Health and Disease. 2011 ; Vol. 2, No. 2. pp. 112-23.

@article{c9030d9d7f9944aeb4058885db9cdda4,

title = "Perinatal programming of murine immune responses by polyunsaturated fatty acids",

abstract = "Linoleic acid and α-linolenic acid are essential fatty acids (eFAs) and have to be acquired from the diet. eFAs are the precursors for long-chain polyunsaturated fatty acids (lcPUFAs), which are important immune-modulating compounds. lcPUFAs can be converted into eicosanoids and other mediators. They affect membrane structure and fluidity and can alter gene expression. There has been a marked change in dietary fatty acid intake over the last several decades. Since eFAs are acquired from the diet and immune development occurs mainly perinatally, the maternal diet may influence fetal and neonatal eFA levels, and thereby lcPUFA status, and thus immune development and function. To study whether early exposure to eFAs can program immune function, mice were fed diets varying in the ratio of ω-3 to ω-6-eFAs during pregnancy and/or lactation. After weaning, pups received a Western-style diet. At 11 weeks of age, the effects of maternal diet on the offspring's allergic and vaccination responses were examined using the T-helper 2 driven ovalbumin-induced allergy model and the T-helper 1 driven influenza-vaccination model, respectively. Offspring of dams fed a high α-linolenic acid diet during lactation showed an enhanced vaccination response. As diets with either low or high ω-3/ω-6-eFA ratio attenuated the T-helper 2 allergic response, the high α-linolenic acid diet fed during lactation had the most pronounced effect. These results indicate that there is a programming effect of maternal diet on the offspring's immune response and that in mice the window of greatest susceptibility to maternal dietary intervention is the lactation/suckling period.",

author = "{van Vlies}, N and A Hogenkamp and Fear, {A L} and {van Esch}, {B C} and A Oosting and {van de Heijning}, B and {van der Beek}, E and Calder, {P C} and J Garssen",

year = "2011",

month = apr,

doi = "10.1017/S204017441000067X",

language = "English",

volume = "2",

pages = "112--23",

journal = "Journal of Developmental Origins of Health and Disease",

issn = "2040-1744",

publisher = "Cambridge University Press",

number = "2",

}

van Vlies, N, Hogenkamp, A, Fear, AL, van Esch, BC, Oosting, A, van de Heijning, B, van der Beek, E, Calder, PC 2011, 'Perinatal programming of murine immune responses by polyunsaturated fatty acids', Journal of Developmental Origins of Health and Disease, vol. 2, no. 2, pp. 112-23. https://doi.org/10.1017/S204017441000067X

Perinatal programming of murine immune responses by polyunsaturated fatty acids. / van Vlies, N; Hogenkamp, A; Fear, A L et al.
In: Journal of Developmental Origins of Health and Disease, Vol. 2, No. 2, 04.2011, p. 112-23.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Perinatal programming of murine immune responses by polyunsaturated fatty acids

AU - van Vlies, N

AU - Hogenkamp, A

AU - Fear, A L

AU - van Esch, B C

AU - Oosting, A

AU - van de Heijning, B

AU - van der Beek, E

AU - Calder, P C

AU - Garssen, J

PY - 2011/4

Y1 - 2011/4

N2 - Linoleic acid and α-linolenic acid are essential fatty acids (eFAs) and have to be acquired from the diet. eFAs are the precursors for long-chain polyunsaturated fatty acids (lcPUFAs), which are important immune-modulating compounds. lcPUFAs can be converted into eicosanoids and other mediators. They affect membrane structure and fluidity and can alter gene expression. There has been a marked change in dietary fatty acid intake over the last several decades. Since eFAs are acquired from the diet and immune development occurs mainly perinatally, the maternal diet may influence fetal and neonatal eFA levels, and thereby lcPUFA status, and thus immune development and function. To study whether early exposure to eFAs can program immune function, mice were fed diets varying in the ratio of ω-3 to ω-6-eFAs during pregnancy and/or lactation. After weaning, pups received a Western-style diet. At 11 weeks of age, the effects of maternal diet on the offspring's allergic and vaccination responses were examined using the T-helper 2 driven ovalbumin-induced allergy model and the T-helper 1 driven influenza-vaccination model, respectively. Offspring of dams fed a high α-linolenic acid diet during lactation showed an enhanced vaccination response. As diets with either low or high ω-3/ω-6-eFA ratio attenuated the T-helper 2 allergic response, the high α-linolenic acid diet fed during lactation had the most pronounced effect. These results indicate that there is a programming effect of maternal diet on the offspring's immune response and that in mice the window of greatest susceptibility to maternal dietary intervention is the lactation/suckling period.

AB - Linoleic acid and α-linolenic acid are essential fatty acids (eFAs) and have to be acquired from the diet. eFAs are the precursors for long-chain polyunsaturated fatty acids (lcPUFAs), which are important immune-modulating compounds. lcPUFAs can be converted into eicosanoids and other mediators. They affect membrane structure and fluidity and can alter gene expression. There has been a marked change in dietary fatty acid intake over the last several decades. Since eFAs are acquired from the diet and immune development occurs mainly perinatally, the maternal diet may influence fetal and neonatal eFA levels, and thereby lcPUFA status, and thus immune development and function. To study whether early exposure to eFAs can program immune function, mice were fed diets varying in the ratio of ω-3 to ω-6-eFAs during pregnancy and/or lactation. After weaning, pups received a Western-style diet. At 11 weeks of age, the effects of maternal diet on the offspring's allergic and vaccination responses were examined using the T-helper 2 driven ovalbumin-induced allergy model and the T-helper 1 driven influenza-vaccination model, respectively. Offspring of dams fed a high α-linolenic acid diet during lactation showed an enhanced vaccination response. As diets with either low or high ω-3/ω-6-eFA ratio attenuated the T-helper 2 allergic response, the high α-linolenic acid diet fed during lactation had the most pronounced effect. These results indicate that there is a programming effect of maternal diet on the offspring's immune response and that in mice the window of greatest susceptibility to maternal dietary intervention is the lactation/suckling period.

U2 - 10.1017/S204017441000067X

DO - 10.1017/S204017441000067X

M3 - Article

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SN - 2040-1744

VL - 2

SP - 112

EP - 123

JO - Journal of Developmental Origins of Health and Disease

JF - Journal of Developmental Origins of Health and Disease

IS - 2

ER -

van Vlies N, Hogenkamp A, Fear AL, van Esch BC, Oosting A, van de Heijning B et al. Perinatal programming of murine immune responses by polyunsaturated fatty acids. Journal of Developmental Origins of Health and Disease. 2011 Apr;2(2):112-23. doi: 10.1017/S204017441000067X