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, Alpen Ortug Division of Newborn Medicine , Department of Medicine, Boston Children’s Hospital, Harvard Medical School , Boston, MA 02115 , United States Department of Radiology , Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital , Charlestown, MA 02129 , United States Department of Radiology, Harvard Medical School , Boston, MA 02115 , United States Search for other works by this author on: Oxford Academic Yurui Guo Division of Newborn Medicine , Department of Medicine, Boston Children’s Hospital, Harvard Medical School , Boston, MA 02115 , United States Search for other works by this author on: Oxford Academic Henry A Feldman Division of Newborn Medicine , Department of Medicine, Boston Children’s Hospital, Harvard Medical School , Boston, MA 02115 , United States Search for other works by this author on: Oxford Academic Yangming Ou Division of Newborn Medicine , Department of Medicine, Boston Children’s Hospital, Harvard Medical School , Boston, MA 02115 , United States Department of Radiology, Harvard Medical School , Boston, MA 02115 , United States Search for other works by this author on: Oxford Academic Jose Luis Alatorre Warren Division of Newborn Medicine , Department of Medicine, Boston Children’s Hospital, Harvard Medical School , Boston, MA 02115 , United States Department of Radiology , Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital , Charlestown, MA 02129 , United States Department of Radiology, Harvard Medical School , Boston, MA 02115 , United States Search for other works by this author on: Oxford Academic Harrison Dieuveuil Division of Newborn Medicine , Department of Medicine, Boston Children’s Hospital, Harvard Medical School , Boston, MA 02115 , United States Search for other works by this author on: Oxford Academic Nicole T Baumer Department of Neurology , Boston Children’s Hospital, Harvard Medical School , Boston, MA 02115 , United States Department of Pediatrics , Boston Children’s Hospital, Harvard Medical School , Boston, MA 02115 , United States Search for other works by this author on: Oxford Academic Susan K Faja Department of Pediatrics , Boston Children’s Hospital, Harvard Medical School , Boston, MA 02115 , United States Division of Developmental Medicine , Laboratories of Cognitive Neuroscience, Boston Children's Hospital , Harvard Medical School, Brookline, MA 02115 , United States Search for other works by this author on: Oxford Academic Emi Takahashi Division of Newborn Medicine , Department of Medicine, Boston Children’s Hospital, Harvard Medical School , Boston, MA 02115 , United States Department of Radiology , Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital , Charlestown, MA 02129 , United States Department of Radiology, Harvard Medical School , Boston, MA 02115 , United States Corresponding author: Building 75, 2.130, 13th street, Charlestown, MA 02129, United States. Email: emi@nmr.mgh.harvard.edu Search for other works by this author on: Oxford Academic
https://orcid.org/0000-0002-7726-6208 Cerebral Cortex, Volume 34, Issue 4, April 2024, bhae117, https://doi.org/10.1093/cercor/bhae117
Published:
10 April 2024
Article history
Received:
18 January 2023
Revision received:
01 March 2024
Accepted:
02 March 2024
Published:
10 April 2024
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Alpen Ortug, Yurui Guo, Henry A Feldman, Yangming Ou, Jose Luis Alatorre Warren, Harrison Dieuveuil, Nicole T Baumer, Susan K Faja, Emi Takahashi, Autism-associated brain differences can be observed in utero using MRI, Cerebral Cortex, Volume 34, Issue 4, April 2024, bhae117, https://doi.org/10.1093/cercor/bhae117
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Abstract
Developmental changes that occur before birth are thought to be associated with the development of autism spectrum disorders. Identifying anatomical predictors of early brain development may contribute to our understanding of the neurobiology of autism spectrum disorders and allow for earlier and more effective identification and treatment of autism spectrum disorders. In this study, we used retrospective clinical brain magnetic resonance imaging data from fetuses who were diagnosed with autism spectrum disorders later in life (prospective autism spectrum disorders) in order to identify the earliest magnetic resonance imaging-based regional volumetric biomarkers. Our results showed that magnetic resonance imaging-based autism spectrum disorder biomarkers can be found as early as in the fetal period and suggested that the increased volume of the insular cortex may be the most promising magnetic resonance imaging-based fetal biomarker for the future emergence of autism spectrum disorders, along with some additional, potentially useful changes in regional volumes and hemispheric asymmetries.
autism spectrum disorder, fetus, MRI, volume, brain segmentation
© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)
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